SYNTHETIC SUBSTITUTES FOR ARTEMISININ DERIVATIVES: SYNTHESIS, CHEMISTRY AND ANTIMALARIAL ASSESSMENT of NEW SERIES of 1,2,4-TRIOXANES

摘要

About 40% of the world populations, living in more than 100 countries are exposed to the risk of malaria. Estimated clinical cases occurring every year is around 300-500 million, of which around 2 million die every year. Emergence of drug-resistant parasite has further compounded the malaria problem. Against this background, the discovery of artemisinin (Quinghaosu 1), as the active principle of the Chinese traditional drug against malaria, Artemisia annua, is a major milestone in the history of malaria chemotherapy.