CALCIUM SILICATE BASED FLOATING GRANULAR DELIVERY SYSTEM of RANITIDINE HYDROCHLORIDE FOR EFFECTIVE MANAGEMENT of PEPTIC ULCER

摘要

The objective of the present investigation was to prepare and evaluate floating granular delivery system for treatment of mucosal ulcer consisting of (i) calcium silicate (CS) as porous carrier; (ii) ranitidine hydrochloride (RH), an anti-ulcer agent; and (iii) hydroxypropyl methylcellulose K4M (HPMC) and ethylcellulose (EC) as matrix forming polymers. The effect of various formulation and process variables on the particle morphology, particle size, micromeritic properties, percent drug content, in vitro floating behavior, and in vitro drug release from the floating granules was studied. The scanning electron microscopy (SEM) of granules revealed that that more pores of CS in secondary coated granules (SCG) were covered by the polymer solution than those in primary coated granules (PCG).