Synthesis and anti-inflammatory activity of 1,4-[bis(3-arylmethane sulfonylvinyl)]benzenes, 1,4-[bis(3-arylmethanesulfonylpyrazolyl and isoxazolyl)]benzenes

Lavanya Gopala; Padmavathi Venkatapuram; Padmaja Adivireddy; Balaji Merigi

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Synthesis and anti-inflammatory activity of 1,4-[bis(3-arylmethane sulfonylvinyl)]benzenes, 1,4-[bis(3-arylmethanesulfonylpyrazolyl and isoxazolyl)]benzenes

机译：1,4- [双（3-芳基甲磺酰基乙烯基）]苯，1,4- [双（3-芳基甲磺酰基吡唑基和异恶唑基）]苯的合成及抗炎活性

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The title compounds were prepared by cycloaddition of nitrile imines and nitrile oxides to the 1,4-bis(E)-2-((arylmethanesulfonyl)vinyl)benzene and studied their anti-inflammatory activity. Among the tested compounds, 6c, 6d, 7c and 7d exhibited promising anti-inflammatory activity.

机译：通过将腈亚胺和腈氧化物环加成到1,4-双（E）-2-（（芳基甲磺酰基）乙烯基）苯上来制备标题化合物，并研究了它们的抗炎活性。在测试的化合物中，6c，6d，7c和7d显示出有希望的抗炎活性。

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《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 |2015年第11期|共9页
作者
Lavanya Gopala; Padmavathi Venkatapuram; Padmaja Adivireddy; Balaji Merigi;
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正文语种 eng
中图分类药学;
关键词
Bis(unsaturated sulfones); Bis(pyrazoles); Bis(isoxazoles); Chloramine-T; Anti-inflammatory activity;

机译：双（不饱和砜）;双（吡唑）;双（异恶唑）;氯胺-T;抗炎活性;

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1. Synthesis and anti-inflammatory activity of 1,4-[bis(3-arylmethane sulfonylvinyl)]benzenes, 1,4-[bis(3-arylmethanesulfonylpyrazolyl and isoxazolyl)]benzenes [J] . Lavanya Gopala, Padmavathi Venkatapuram, Padmaja Adivireddy, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2015,第11期

机译：1,4- [双（3-芳基甲磺酰基乙烯基）]苯，1,4- [双（3-芳基甲磺酰基吡唑基和异恶唑基）]苯的合成及抗炎活性
2. Synthesis of 1,3-and 1,4-bis(3-nitrofurazan-4-yl)benzenes and isomeric 1,3-and 1,4-bis[3(4)-nitrofuroxan-4(3)-yl]benzenes [J] . Ovchinnikov Igor V., Finogenov Alexey O., Epishina Margarita A., Mendeleev Communications . 2009,第4期

机译：1,3-和1,4-双（3-硝基呋喃山-4-基）苯和异构的1,3-和1,4-双[3（4）-硝基呋喃喃-4（3）-基]苯的合成
3. A practical synthesis of 1,4-diiodo-2,5-bis(chloromethyl)benzene and 1,4-diiodo-2,5-bis(bromomethyl)benzene [J] . Gaefke G, Enkelmann V, Hoger S Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2006,第17期

机译：实用合成1,4-二碘-2,5-双（氯甲基）苯和1,4-二碘-2,5-双（溴甲基）苯
4. Synthesis, characterization, magnetic properties of cobalt coordination polymer based on 4,4'-Oxybisbenzoic acid and 1,4-bis(pyrid-4-yl)benzene [C] . Fengping Xiao, Peng Hu International Conference on Material Science, Energy and Environmental Engineering . 2017

机译：基于4,4'-氧基苯甲酸和1,4-双（Pyrid-4-基）苯的钴配位聚合物的合成，表征，磁性性能
5. The synthesis and reactivity of an alkyl-substituted derivative of m-xylylene: Benzene-1,3-diylbis(2-adamantyl) [D] . Currey, Jo Ann 1999

机译：间亚二甲苯基的烷基取代衍生物：苯-1,3-二基双（2-金刚烷基）的合成与反应性
6. {μ2-1,4-Bis[2-(4-pyridyl)ethenyl]benzene-κ2N:N′}bis[bis(acetylacetonato-κ2O,O′)copper(II)] [O] . Fang-Fang Jian, Jing Wang, Jing Zhang 2016

机译：{μ2-1,4-双[2-（4-吡啶基）乙炔基]苯-κ2N：N'} bis [bis（乙酰丙酮-κ2O，O'）铜（II）]
7. Poly[[[silver(I)-μ-1,4-bis[(imidazol-1-yl)methyl]benzene-κ2N3:N3′-silver(I)-μ-1,4-bis[(imidazol-1-yl)methyl]benzene-κ2N3:N3′] 4,4′-diazenediyldibenzoate] dihydrate] [O] . Qian Qiao, Mei Tian, Da-Yong Liu, 2011

机译：聚[[[银（I）-＆＃956; -1,4-双[（咪唑-1-基）甲基]苯]-＆＃954; 2N3：N3＆＃8242;-银（I）-＆＃956 ； -1,4-双[（咪唑-1-基）甲基]苯-＆＃954; 2N3：N3＆＃8242;] 4,4＆＃8242;-二烯二烷基二苯甲酸酯]二水合物]
8. Solid State Solution Behavior of Triorganotin (IV) Derivatives Containing the2,4,6-Tris-(Triflu oromethyl)Benzene 1,4-Bis(Perfluoroisopropoxy) Tetrafluorobenzene Ligands: Crystal Molecular Structures of 2,4,6-(CF3)3C6H2Sn(C6H5)3 and 1,4-(CH3)SnOC(CF)32C6F [R] . Vij, A., Kirchmeier, R. L., Willett, R. D., 1994

机译：含有2,4,6-三 - （三氟甲基）苯1,4-双（全氟异丙氧基）四氟苯配体的三有机锡（Ⅳ）衍生物的固态溶液行为：2,4,6-（CF3）3C6H2sn的晶体分子结构（ C 6 H 5）3和1,4-（CH 3）snOC（CF）32C6F

Synthesis and anti-inflammatory activity of 1,4-[bis(3-arylmethane sulfonylvinyl)]benzenes, 1,4-[bis(3-arylmethanesulfonylpyrazolyl and isoxazolyl)]benzenes

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