Neuroprotective effect of bisabolangelone on hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells

摘要

Bisabolangelone is the main active ingredient of Angelica polymorpha, which has the good pharmacological activities such as anti-celialgia, anti-dysmenorrhea and anti-gastralgia. In this study, the neuroprotective effect of bisabolangelone against hydrogen peroxide (H2O2)-induced neurotoxicity in human neuroblastoma cells was studied. The binding capacity between bisabolangelone and calcium channel was calculated by molecular docking method, and calcium concentration was detected by the calcium fluorescent probe of Fura-2 AM. The results indicated that bisabolangelone had a good neuroprotective effect on nerve cells by interacting with calcium channels, mainly blocking the voltage-gated calcium channels, suppressing calcium releasing from the calcium store.