Antihepatotoxic, nephroprotective, and antioxidant activities of phenolic compounds from Satureja macrostema leaves against carbon tetrachloride-induced hepatic damage in mice

摘要

Satureja macrostema (SM) is used with culinary and medicinal purposes. Methanol extract from SM was investigated for its phenolic content, antioxidant, hepato-protective, and kidney protective activities. Liver and kidney damage were induced in rats with CCI4. Hepatoprotective efficacy was measured by the activity of aspartate amino-transferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, cholesterol, high density lipoprotein and total protein, and lipid peroxidation. Kidney function was evaluated by measuring plasma urea and creatinine. Antioxidant activity was evaluated by measuring blood glutathione content, superoxide dismutase and catalase activities, and mal-ondialdehyde equivalent; their activity was comparable to that of silymarin, a well-known hepatoprotective agent.