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The protective effects of oxyresveratrol imine derivative against hydrogen peroxide-induced cell death in PC12 cells

机译:氧白藜芦醇亚胺衍生物对过氧化氢诱导的PC12细胞死亡的保护作用

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Oxyresveratrol (2',3,4',5-tetrahydroxystilbene) is a naturally occurring ingredient found in mulberries that shows potential as an antioxidant, anti-inflammatory, and neuroprotective agent. This study was performed to identify materials similar to oxyresveratrol that may have more effective antioxidant properties. We synthesized a stilbene analog referred to as Compound 1 (2',3,4',5-tetramethoxystilbene); a benzamide analog referred to as Compound 2 ((2,4-dimethoxyphenyl)-3,5-dimethoxybenzamide); and three imine analogs referred to as Compound 3 (3,5-dimethoxybenzylidene)-(2,4-dimethoxyphenylamine), Compound 4 ((4-methoxybenzylidene)-(3-methoxyphenyl)amine), and Compound 5 ((4-methoxybenzylidene)phenylamine). The cytoprotective effects of these compounds were subsequently evaluated using hydrogen peroxide-treated PC12 cells. The cytoprotective effects of the imine analogs were greater than the effects of oxyresveratrol and the other analogs at concentrations of 200 μM. The Compound 3, which is the most effective imine analog of oxyresveratrol, exhibited these cytoprotective effects against hydrogen peroxide-induced oxidative stress through the regulation of heme oxygenase-1 (HO-1) expression and the translocation of nuclear factor E2-related factor 2 (Nrf2). Our results suggest that imine analogs of oxyresveratrol may be useful agents in reducing neuronal oxidative damage.
机译:土白藜芦醇(2',3,4',5-四羟基hydroxy)是桑树中的天然成分,具有抗氧化剂,抗炎剂和神经保护剂的潜力。进行这项研究的目的是鉴定类似于氧白藜芦醇的材料,这些材料可能具有更有效的抗氧化性能。我们合成了一种称为化合物1的二苯乙烯类似物(2',3,4',5-四甲氧基苯乙烯);称为化合物2的苯甲酰胺类似物((2,4-二甲氧基苯基)-3,5-二甲氧基苯甲酰胺);和三个亚胺类似物,分别称为化合物3(3,5-二甲氧基亚苄基)-(2,4-二甲氧基苯胺),化合物4((4-甲氧基苄基)-(3-甲氧基苯基)胺)和化合物5((4-甲氧基苄基) )苯胺)。随后使用过氧化氢处理的PC12细胞评估了这些化合物的细胞保护作用。在浓度为200μM时,亚胺类似物的细胞保护作用大于氧化白藜芦醇和其他类似物的作用。化合物3是氧白藜芦醇最有效的亚胺类似物,通过调节血红素加氧酶-1(HO-1)的表达和核因子E2相关因子2的易位,对过氧化氢诱导的氧化应激表现出这些细胞保护作用。 (Nrf2)。我们的结果表明,氧白藜芦醇的亚胺类似物可能是减少神经元氧化损伤的有用药物。

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