Antiphospholipid syndrome is characterized by thromboembolism or recurrent pregnancy loss in association with antibodies to certain plasma proteins-most commonly, lupusranti-coagulant, anticardiolipin, and anti-beta_2 glycoprotein antibodies.A variety of clinical manifestations have been reported. In a series of 1,000 patientswith antiphospholipid syndrome, deep venous thrombosis occurred in 32%, thrombocytopenia in 22%, livedo reticularis in 20%, stroke in 13%, superficial thrombophlebitis in 9%, pulmonary embolism in 9%, fetal loss in 8%, transient ischemic attack in 7%, and hemolytic anemia in 7%.
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