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Evaluation of flexible and rigid (class solution) radiation therapy conformal prostate planning protocols

机译:柔性和刚性(分类溶液)放射治疗适形前列腺计划方案的评估

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Protocols commonly implemented in radiotherapy work areas may be classified as being either rigid (class solution) or flexible. Because formal evaluation of these protocol types has not occurred within the literature, we evaluated the efficiency of a rigid compared with flexible prostate planning protocol by assessing a series of completed 3D conformal prostate plans. Twenty prostate cancer patients with an average age of 70 years (range, 52-77) and sizes comprising 8 small, 10 medium, and 2 large were planned on the Phillips Pinnacle treatment planning system 6 times by radiation therapists with <2 years, 2-5 years, and >5 years of experience using a rigid and flexible protocol. Plans were critiqued using critical organ doses, confirmation numbers, and conformity index. Plans were then classified as being acceptable or not. Plans produced with the flexible protocol were 53% less likely to require modification (OR 0.47, 95% CI: 0.26, 0.84, p = 0.01). Planners with >5 years of experience were 78% more likely to produce plans requiring modification (OR 1.78, 95% CI: 1.12, 2.83, P = 0.02). Plans according to the flexible protocol took longer (112 min) compared with the time taken using a rigid protocol (68 min) (p < 0.001). The results suggest that further studies are needed; however, we propose that all radiation therapy planners should start with the same limitations, and if an acceptable plan is not reached, then flexibility should be given to improve the plan to meet the desired results.
机译:通常在放射治疗工作区域中实施的协议可以分为严格的(分类解决方案)或灵活的。由于在文献中尚未对这些协议类型进行正式评估,因此我们通过评估一系列完整的3D保形前列腺计划,评估了与刚性前列腺计划协议相比,刚性疗法的效率。由Phillips Pinnacle治疗计划系统计划了20例平均年龄为70岁(范围52-77)且大小分别为8个小,10个中号和2个大的前列腺癌患者,其中2岁以下的放射治疗师计划进行6次,2 -5年,并且使用严格而灵活的协议具有超过5年的经验。使用关键器官剂量,确认号和合格指数对计划进行了评论。然后将计划分类为可接受或不可接受。使用灵活协议生成的计划需要修改的可能性降低了53%(OR 0.47、95%CI:0.26、0.84,p = 0.01)。具有5年以上经验的规划师,更有可能制定需要修改的计划(OR 1.78,95%CI:1.12,2.83,P = 0.02)。与使用刚性协议所需的时间(68分钟)相比,根据柔性协议进行的计划花费了更长的时间(112分钟)(p <0.001)。结果表明需要进一步研究;但是,我们建议所有放射治疗计划者应从相同的限制入手,如果未达到可接受的计划,则应给予灵活性以改进计划,以达到所需的结果。

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