There has been a rapid expansion of the use of intravenous immunoglobulin (IVIG) for an ever-growing number of conditions. IVIG is used at a 'replacement dose' (400-600 mg/kg/ month) in antibody deficiencies and is used at a high dose (2 g/kg) as an 'immunomodu-latory' agent in an increasing number of immune and inflammatory disorders.1 The limitations for IVIG are the cost of the preparation and the need for intravenous infusions. Due to the cost, shortages and growing use of IVIG there have been attempts to develop evidence-based guidelines for the use of IVIG in a wide variety of immune disorders in children and neonates. This commentary provides the recommendations and recent publication regarding the use of IVIG in various conditions in children.
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机译：对于越来越多的疾病，静脉免疫球蛋白（IVIG）的使用已迅速扩展。 IVIG在抗体缺陷时以“替代剂量”（400-600 mg / kg /月）使用，在高剂量（2 g / kg）中作为“免疫调节”剂使用，其免疫功能越来越高。炎症性疾病。1IVIG的局限性在于制备成本和需要静脉输液。由于IVIG的成本，短缺和日益增长的使用，已经尝试开发基于证据的指南，以将IVIG用于儿童和新生儿的多种免疫疾病。该评论提供了有关在儿童各种状况下使用IVIG的建议和最新出版物。
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