'Spontaneous molecular reactivation' of herpes simplex virus type 1 in the brain as a pathogenic mechanism of Alzheimer's disease.

摘要

Extensive research has focused on the neuropathogenesis of Alzheimer's disease (AD) due to an urgent need for effective preventive and therapeutic measures. AD neuropathology encompasses accumulation of neurotoxic p-amyloid (Ap) and hyperphosphoryl-ated tau proteins, leading to neurodegeneration.Herpes simplex virus type 1 (HSV-1) is a ubiquitous neuro-tropic virus among humans. The virus establishes a lifelong latent infection in the peripheral nervous system, usually in the trigeminal ganglia. Infected individuals usually remain asymptomatic, but the virus is reactivated during stress and immunosuppression.