Why don't pigs get diabetes? Explanations for variations in diabetes susceptibility in human populations living in a diabetogenic environment.

摘要

Type 2 diabetes is growing in prevalence at different rates in different populations. In developed countries, where rates are rising relatively slowly, the age-adjusted prevalence of diabetes ranges from about 5% among people of European ancestry to 40% or higher in Aboriginal populations. In developing countries, progressive westernization is followed by a rapid rise in diabetes prevalence. For example, according to current trends, the prevalence of diabetes in India and China is expected to double by 2030, whereas globally it is expected to rise by only 61%. This growth is due in part to a rise in prevalence among children and young adults in the developing world. (The estimated prevalence and age distribution of diabetes in developed and developing countries in 1995 and 2000 are presented in an online table available at www.cmaj.ca/cgi/content/full/174 /1/25/DC1.)