Balancing and imbalancing effects of astrocytic receptors in tripartite synapses. Common pathophysiological model of mental disorders and epilepsy

摘要

Based on a logic of balance mechanisms influencing information processing in tripartite synapses are proposed. It is hypothesized that the number of expressed astrocytic receptors determines balanced and imbalanced synaptic states. Synaptic information processing in mental disorders is underbalanced in depression, overbalanced in mania, and completely unbalanced in schizophrenia. The synaptic pathophysiology of the epileptic syndrome may also be based on comparable imbalances. In addition, this model of synaptic balancing enables a deduction in explaining the therapeutic effect of ECT in therapy resistant depression. Together, the model proposed may represent a contribution to the search for common synaptic mechanisms in normal brains and its various disorders. (c) 2015 The Author. Published by Elsevier Ltd.