Luminal Na~+ homeostasis has an important role in intestinal peptide absorption in vivo

摘要

Intestinal cell line studies indicated luminal Na+ homeostasis is essential for proton-coupled peplide absorption, because the driving force of PepTI activity is supported by the apical Na~+/H~+ exchanger NHE3. However, there is no direct evidence demonstrating the importance of in vivo luminal Na~+ for peptide absorption in animal experiments. To investigate the relationship between luminal Na+ homeostasis and peptide absorption, we took advantage of claudin 15-deficient (cldnl5~/~) mice, whereby Na~+ homeostasis is disrupted.