Conserved mechanisms of Mycobacterium marinum Pathogenesis within the environmental amoeba Acanthamoeba castellanii

摘要

Mycobacterium marinum is a waterbornemycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum. We demonstrate that the ESX-1 secretion system is required for M. marinum pathogenesis and that M. marinum utilizes actin-based motility in amoebae. Therefore, at least two virulence pathways used by M. marinum in macrophages are conserved during M. marinum infection of amoebae.