首页> 外文期刊>European neurology >Differences in Brain Natriuretic Peptide Value between Transient Ischemic Attack and Stroke Patients with Atrial Fibrillation.
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Differences in Brain Natriuretic Peptide Value between Transient Ischemic Attack and Stroke Patients with Atrial Fibrillation.

机译:短暂性脑缺血发作和中风房颤患者脑钠肽值的差异。

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摘要

Purpose: The present study investigated clinical characteristics including plasma brain natriuretic peptide (BNP) among transient ischemic attack (TIA) and stroke patients with atrial fibrillation (AF). Methods: We prospectively enrolled 227 consecutive patients with AF within 24 h of onset of TIA or stroke, and plasma BNP was measured on admission. Patients were divided into 2 groups: TIA and stroke groups. The factors associated with TIA were investigated by multivariate logistic regression analysis. Results: 21 patients (9.3%) were diagnosed with TIA, and 206 patients (90.7%) with stroke. The plasma BNP level of the TIA group was significantly lower than that of the stroke group [median (interquartile range) 86.5 (72.7-189.0) pg/ml vs. 269.0 (146.0-432.0) pg/ml, p = 0.0002]. The optimal cutoff level, sensitivity, and specificity of BNP levels to distinguish the TIA group from the stroke group were 120 pg/ml, 79.1 and 66.7%, respectively. Multivariate logistic regression analysis demonstrated that pre-admission warfarin use (OR 3.7; 95% CI 1.178-11.570, p = 0.0250), glucose of
机译:目的:本研究调查了短暂性脑缺血发作(TIA)和中风并发房颤(AF)患者的血浆脑利钠肽(BNP)的临床特征。方法:我们前瞻性地在TIA或中风发作的24小时内招募了227例AF患者,并在入院时对其血浆BNP进行了测量。患者分为两组:TIA和中风组。通过多元logistic回归分析研究了与TIA相关的因素。结果:21例患者(9.3%)被诊断患有TIA,206例患者(90.7%)被诊断为中风。 TIA组的血浆BNP水平显着低于中风组[中位(四分位间距)86.5(72.7-189.0)pg / ml与269.0(146.0-432.0)pg / ml,p = 0.0002]。将TIA组与中风组区分开的最佳BNP水平,敏感性和特异性分别为120 pg / ml,79.1和66.7%。多元逻辑回归分析表明,入院前使用华法林(OR 3.7; 95%CI 1.178-11.570,p = 0.0250),葡萄糖≤120 mg / dl(OR 5.1; 95%CI 1.629-16.238,p = 0.0052 )和血浆BNP≤120pg / ml(OR 6.1; 95%CI 1.967-18.931,p = 0.0017)与TIA独立相关。结论:在房颤患者中,TIA患者的入院时BNP值低于中风患者。因此,TIA和中风发作时,心脏功能可能与神经系统严重程度有关。

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