Bioresorbable Hydrogels Prepared Through Stereocomplexation between Poly(L-lactide) and Poly(D-lactide) Blocks Attached to Poly(ethylene glycol)

摘要

Block copolymers were synthesized by ring-opening polymerization of L-lactide or D-lactide in the presence of mono- or dihydroxyl poly(ethylene glycol), using zinc metal as catalyst. The resulting copolymers were characterized by various techniques, namely ~1H NMR spectroscopy, differential scanning calorimetry (DSC), X-ray diffractometry, and Raman spectrometry. The composition of the copolymers was designed such that they were water soluble. Bioresorbable hydrogels were prepared from aqueous solutions containing both poly(L-lactide)/poly(ethylene glycol) and poly(D-lactide)/poly(ethylene glycol) block copolymers. Rheological studies confirmed the formation of hydrogels resulting from stereocomplexation between poly(L-lactide) and poly(D-lactide) blocks.