Landiolol and peri-induction tachycardia.

摘要

We read with interest the recently published article by Yamazaki et al. The authors describe the role of landiolol, a new beta_1 selective antagonist in attenuating tachycardia in response to tracheal intubation. The authors conclude that landiolol [0.1 mg-kg~(-1) (LI group) and 0.3 mg-kg~(-1) (L3 group)] prevents tachycardia without affecting blood pressure. However, the results indicate that there was no difference in heart rate (HR) values between the control group and LI group. We believe that this may be related to the anesthetic induction technique, which comprised propofol (2 mg-kg~(-1)) and succinylcholine (1 mg-kg~(-1)). It is well known that propofol as well as succinylcholine are associated with a decrease in HR. Further, it is unclear as to when vecuronium was administered during the induction-intubation sequence: as this may have presented an additional confounding factor.