Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

摘要

Surfactant-free honeycomb-structured Poly(DLlactide) (PDLLA) and Poly-(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.