Histological Evaluation of Degradable Guided Bone Regeneration Membranes Prepared from Poly(trimethylene carbonate) and Biphasic Calcium Phosphate Composites

摘要

In oral and maxillofacial surgery, guided bone regeneration using barrier membranes is an important strategy to treat bone defects. The currently used barrier membranes have important disadvantages. Barrier membranes prepared from resorbable poly(trimethylene carbonate) (PTMC) performed as well as collagen barrier membranes. We hypothesized that composite membranes prepared from surface-eroding PTMC and osteoinductive biphasic calcium phosphate (BCP) would enhance bone formation even further. Bicortical critical size defects in the mandibular angle of rats were covered on both sides with the membranes. After 2, 4, and 12 weeks the extent of bone formation in the defects and the soft tissue reaction towards the membranes was examined histologically. At 2 and 4 weeks, the formation of new bone was observed in defects covered with PTMC, PTMC-BCP and Biogide collagen membranes. At 12 weeks, bone defects that were covered with PTMC membranes and control Biogide collagen membranes were fully filled with new formed bone. However, at this time point, defects covered with PTMC-BCP composite membranes had not led to new bone in the defects. Instead a significant tissue reaction, likely to remaining BCP particles, was observed.