Clinical outcome in dogs with nasal tumors treated with intensity-modulated radiation therapy

摘要

Intensity-modulated radiation therapy (IMRT) is a valuable tool in human radiation oncology, but information on its use in veterinary medicine is lacking. In this Study, 12 dogs with nasal tumors were created with PORT at a median radiation dose of 54 Gy. Patient survival times and frequency and severity of side effects oil Ocular structures, oral mucosa, and skin were recorded. Light dogs (67%) had resolution of clinical signs during radiation therapy. Median overall survival rime was 446 d with a 50% 1-year and a 25% 2-year survival rate. Minimal grade 2 or 3 acute skin toxicity, no grade 2 or 3 late skin toxicity, and no grade 2 or 3 toxicity to oral mucosa or the eye opposite the tumor were identified in the dogs treated with IMRT in this study. The ipsilateral eye could nor be routinely spared due to its proximity to the tumor.