We read with interest the article by Sharma et al. in which they attribute symptoms mimicking a postdural puncture headache to the administration of ondansetron.1 We again highlight this clinically relevant though understated side effect of ondansetron. We present a case of severe migraine that was precipitated in a young female following the administration of ondansetron for the prophylaxis of postoperative nausea and vomiting (PONV). Consent to publish details about this case was obtained from the patient.A 26-yr-old female was admitted for debridement of an infected wound following a cat scratch to her hand. Her medical history included depression, mild asthma, and occasional migraines.
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