Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia

摘要

More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasmsthe most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.