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Advances in the molecular imaging of multiple sclerosis.

机译:多发性硬化的分子影像学研究进展。

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Molecular imaging has had little application to multiple sclerosis thus far. However, advances in preclinical studies and proofs-of-principle provided for other inflammatory disorders highlight the potential for using positron emission tomography, single-photon emission computerized tomography or MRI-based molecular imaging methods to define the distribution and trafficking of specific immune effector cells, or to follow changes in specific molecular neuropathology in multiple sclerosis. If this promise can be realized, novel insights into the dynamics of in vivo multiple sclerosis neuropathology can be expected. Furthermore, powerful new approaches to testing the pharmacology of novel therapeutics will become possible. Molecular imaging could also contribute to 'personalizing' treatments for better outcomes.
机译:迄今为止,分子成像在多发性硬化中几乎没有应用。但是,临床前研究的进展和为其他炎症性疾病提供的原理证明突出显示了使用正电子发射断层扫描,单光子发射计算机断层扫描或基于MRI的分子成像方法来定义特定免疫效应细胞分布和运输的潜力。 ,或追踪多发性硬化症中特定分子神经病理学的变化。如果能够实现这一诺言,则有望获得体内多发性硬化症神经病理学动力学的新见解。此外,强大的新方法可用于测试新型疗法的药理学。分子成像还可以有助于“个性化”治疗,以获得更好的结果。

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