Cholinergic urticaria (CU) can be defined as itching and whealing associated with exercise, hot showers, sweating, anxiety, or any other condition that increases the body's core temperature. Cholinergic urticaria might present in a local or generalized form. The latter is characterized by the abrupt appearance of small wheals surrounded by a pronounced erythematous flare reaction beginning over the upper thorax and neck and subsequently spanning practically the entire body. Exercise-induced anaphylaxis should be ruled out.
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