Que sera, sera: evolution of the swine H1N1 influenza A virus.

摘要

A new human influenza A virus (IAV) strain of swine-like origin emerged in Mexico and the USA in March and April of 2009 [i]. The virus disseminated globally with such celerity that on 11 June 2009, the WHO raised the Flu Pandemic Alert Level to Phase 6, officially designating a new global pandemic. At the time, there were 30,000 confirmed cases in 74 countries. Less than 1 month later (as of 1 July 2009), the WHO confirmed over 77,000 cases and 332 deaths worldwide.The collaborative nature of the global response to the outbreak has been remarkafele. Within days of the initial reporting of the virus, researchers completely sequenced the genome of several viral isolates and posted the sequences on the internet. Sequences of new isolates continue to be uploaded daily on websites such as the Global Initiative on Sharing Avian Influenza Data [101] and the National Center for Biotechnology Information [102]. Nearly in real time, phylogeneticists identified the complex origins of the virus. Within weeks, a vaccine seed stock was isolated, and the private and public sector began intense collaborative efforts to produce a vaccine post-haste [2].