Tooth loss might not alter molecular pathogenesis in an aged transgenic Alzheimer's disease model mouse

摘要

Background and objectivePrevious studies have reported that tooth loss is a risk factor of Alzheimer's disease (AD). However, the association between tooth loss and cognition and the impact of tooth loss on the molecular pathogenesis of AD remain elusive. In this study, we tested the effect of tooth loss on learning and memory and on the molecular pathogenesis of AD in an aged AD model mice.