Chitotriosidase levels in patients with severe endometriosis

摘要

Objective: To study the levels of chitotriosidase activity in the peritoneal fluid and the plasma of patients with severe endometriosis and control subjects. Materials and methods: Twenty-five women with laparoscopically and histopathologically confirmed endometriosis (study group) and 27 control patients who had undergone laparoscopic surgery were included. Peritoneal fluid and peripheral blood were obtained from all the patients before the surgery. Chitotriosidase activities were measured. Results: Analysis of chitotriosidase activity in the peritoneal fluid of patients with endometriosis showed that there was no significant difference between endometriosis and control group, respectively (32.04±64.20 vs. 15.25±31.17 nmol/mL/h; p>0.05). Analysis of chitotriosidase activity in plasma of patients with endometriosis showed significantly increased levels of chitotriosidase levels compared with the control group (74.81±60.54 vs. 14.10±26.17; p<0.001), respectively. Conclusion: We found that the activity of chitotriosidase in plasma was statistically higher in severe endometriosis patients than women without endometriosis.