DEATH, FOLLOWING THE REGRESSION OF TRANSMISSIBLE VENEREAL TUMOR (TVT) IN A NIGERIAN LOCAL MALE DOG (MONGREL) TREATED WITH ONCOVIN (VINCRISTINE) (CASE REPORT)

摘要

The possible effects of vincristine sulphate administration to a male dog which had Transmissible venereal tumour (TVT) were studied. A weekly intravenous (i.v.) injection of 0.025 mg kg~(-1) vincristine sulphate was administered in the first 2 weeksand the dose halved for the next 4 weeks. Vitamin B-complex and 5% dextrose solution were also administered i.v. By the 5th week, significant reduction in the size and firmness of tumour as well as fluid exsu-dation were noticed. The dog later became anorexic and recumbent with persistent crying. Death followed 2 weeks after the end of the six-week period of treatment. The study indicates that vincristine sulphate is effective against canine TVT but death of the subject may occur afterwards, probably due to toxicosis.