Screening the experimental domain for the microwave-assisted extraction of secoisolariciresinol diglucoside from flaxseed prior to optimization procedures.

摘要

This paper presents the first part of a study that aims at developing an optimized microwave-assisted method for extracting the lignan secoisolariciresinol diglucoside from defatted flaxseed meal. Two-level fractional factorial designs were used for screening the following factors: the microwave power level (30-360 W), the time of residence in the microwave cavity (1-25 min), the concentration of NaOH (0.25-1 M), and the mode of microwave power application (power on 30 and 60 s/min). The experimental domain had to be adjusted after each screening in order to focus the future optimization study within the factors' ranges likely to contain the optimal extraction conditions.