Bioactive compounds from an endophytic fungus from eastern larch (Larix laricina) needles

摘要

The structures of two novel metabolites isolated from cultures of an unidentified endophytic fungus obtained from an eastern larch (Larix laricina (Du Roi) K. Koch) needle were shown to be 8,1',5'-trihydroxy-3',4'dihydro-1'H-[2,4']binaphthalenyl-1,4,2'-trione, 1, and 2-methyloctanoic acid 6-oxo-2-propenyl-3,6-dihydro-2H-pyran-3-yl ester, 2. Structures were determined by spectroscopic means. Compound 1 was toxic to spruce budworm (Choristoneura fumiferana Clem.) larvae while 2 was active against Vibrio salmonicida, Pseudomonas aeruginosa, and Staphylococcus aureus.