Sesquiterpene lactones from Sonchus arvensis L. and their antibacterial activity against Streptococcus mutans ATCC 25175

摘要

Two new sesquiterpene lactones,1 beta-sulfate-5 alpha, 6 beta H-eudesma-3-en-12, 6 alpha-olide (1) and 1 beta-(p-hydroxyphenyl acetyl)-15-O-beta-D-glucopyranosyl-5 alpha, 6 beta H-eudesma-3-en-12, 6 alpha-olide (2) were isolated from Sonchus arvensis L (Asteraceae), together with eight known compounds. Their structures were elucidated through spectroscopic and chemical methods. They were evaluated for antibacterial activity. Among them, compounds 1 and 7 exhibited antibacterial activity against oral pathogen Streptococcus mutans ATCC 25175 with MIC values of 15.6 and 62.5 mu g/ml, respectively.