Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing.

Huntriss J; Woodfine K; Huddleston JE; Murrell A; Rutherford AJ; Elder K; Khan AA; Hemmings K; Picton H

首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing.

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Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing.

机译：通过焦磷酸测序对单个人胚泡中印迹基因的DNA甲基化进行定量分析。

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We report the first quantitative assessment of DNA methylation for any gene in the human preimplantation embryo to reveal that imprints exist at KvDMR1, RB1, SNRPN, and GRB10 in the human blastocyst. For comparison, in two human embryonic stem cell lines, imprints were also observed at KvDMR1, SNRPN, GRB10, and other imprinted loci, whereas RB1 and MEG3 were hypermethylated.

机译：我们报告了人类植入前胚胎中任何基因的DNA甲基化的首次定量评估，以揭示在人类胚泡中的KvDMR1，RB1，SNRPN和GRB10存在印记。为了进行比较，在两种人类胚胎干细胞系中，在KvDMR1，SNRPN，GRB10和其他印迹基因座上也观察到印迹，而RB1和MEG3被高度甲基化。

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《Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society》 |2011年第8期|共4页
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Huntriss J; Woodfine K; Huddleston JE; Murrell A; Rutherford AJ; Elder K; Khan AA; Hemmings K; Picton H;
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正文语种 eng
中图分类妇科学;
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1. Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing. [J] . Huntriss J, Woodfine K, Huddleston JE, Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society . 2011,第8期

机译：通过焦磷酸测序对单个人胚泡中印迹基因的DNA甲基化进行定量分析。
2. Novel imprinted single CpG sites found by global DNA methylation analysis in human parthenogenetic induced pluripotent stem cells [J] . Choi Na Young, Bang Jin Seok, Lee Hye Jeong, Epigenetics: official journal of the DNA Methylation Society . 2018,第4期

机译：通过全球性DNA甲基化分析在人脑发生诱导多能干细胞中发现的新型印迹单CPG位点
3. Genome-wide DNA methylation analysis of single and pooled human blastocysts [J] . Huntriss J., Carr I, Miller D., Chromosome research: An international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology . 2014,第4期

机译：全基因组DNA甲基化分析单个和合并的人类胚泡。
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Role of epigenetic regulation in human sperm and egg analysis of DNA methylation and polyA regulation. [D] . Pfluger, Christian. 2015

机译：表观遗传调控在人类精子中的作用和卵中DNA甲基化和polyA调控的分析。
6. Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue [O] . Kathryn Woodfine, Joanna E Huddleston, Adele Murrell 2011

机译：对所有人类印迹区域的DNA甲基化的定量分析表明在成年体细胞组织中表观遗传稳定性得以保留
7. Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue [O] . Woodfine Kathryn, Huddleston Joanna E, Murrell Adele 2011

机译：对所有人类印迹区域的DNA甲基化的定量分析表明，在成年体细胞组织中表观遗传稳定性得以保留

Quantitative analysis of DNA methylation of imprinted genes in single human blastocysts by pyrosequencing.

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