Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection.

摘要

OBJECTIVE: To analyze the role of luteal E(2), P, and FSH levels in the prediction of clinical pregnancy in stimulated cycles. DESIGN: Prospective study. SETTING: Institute of Reproductive Medicine, Salt Lake, Kolkata, India. PATIENT(S): A total of 268 women aged <40 years undergoing their first IVF-ET/intracytoplasmic sperm injection cycles. INTERVENTION(S): Estimation of luteal phase serum E(2), P, and FSH levels on days 0, 7, and 14 of ET. MAIN OUTCOME MEASURE(S): Comparison of luteal phase hormonal profile in pregnant and nonpregnant women and interpretation by discriminant analysis. RESULT(S): A total of 113 pregnancies were achieved (42.16%). Age, basal FSH level, peak E(2) level, number of oocytes retrieved, and number of embryos transferred were comparable between pregnant and nonpregnant women. Day-7 and day-14 luteal E(2) levels were significantly different between the two groups. Progesterone levels were comparable in both groups on days 0 and 14. Levels of FSH showed statistically significant differences between the two groups on days 0, 7, and 14. Classification accuracy for E(2), P, and FSH was 82.1%, 60.8%, and 67.51%, respectively. CONCLUSION(S): Luteal E(2) concentration seems to be a promising marker of successful clinical pregnancy.