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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Estrogen induces stromal cell-derived factor 1 (SDF-1/CXCL12) production in human endometrial stromal cells: a possible role of endometrial epithelial cell growth.
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Estrogen induces stromal cell-derived factor 1 (SDF-1/CXCL12) production in human endometrial stromal cells: a possible role of endometrial epithelial cell growth.

机译:雌激素在人子宫内膜间质细胞中诱导基质细胞衍生因子1(SDF-1 / CXCL12)的产生:子宫内膜上皮细胞生长的可能作用。

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摘要

Estradiol enhanced stromal cell-derived factor 1 (SDF-1/CXCL12) production levels in human endometrial stromal cells (ESCs) in a time- and dose-dependent manner that could be completely abolished by ICI 182,780 (estrogen receptor antagonist) and medroxyprogesterone acetate. Although SDF-1 was undetectable in the Ishikawa human endometrial epithelial cell line, its receptor (CXCR4) messenger RNA levels in Ishikawa cells were much higher than those in ESCs, and furthermore SDF-1 induced the proliferation of Ishikawa cells; SDF-1 secreted from ESCs may play a role in endometrial epithelial cell growth in the paracrine system.
机译:雌二醇以时间和剂量依赖性方式增强了人子宫内膜基质细胞(ESC)中基质细胞衍生的因子1(SDF-1 / CXCL12)的生产水平,而ICI 182,780(雌激素受体拮抗剂)和醋酸甲羟孕酮可以完全消除雌二醇。尽管在石川人类子宫内膜上皮细胞系中未检测到SDF-1,但石川细胞中其受体(CXCR4)信使RNA的水平远高于ESC中的SDF-1,而且SDF-1诱导了石川细胞的增殖。 ESC分泌的SDF-1可能在旁分泌系统的子宫内膜上皮细胞生长中起作用。

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