p53 death signal is mainly mediated by Nud(EndoG) in the yeast Saccharomyces cerevisiae

摘要

The tumor suppressor p53 plays a central role in the regulation of cellular growth and apoptosis. In the yeast Saccharomyces cerevisiae, the overexpression of the human p53 leads to growth inhibition and apoptotic cell death on minimal medium. In thepresent work, we show that p53-expressing cells are more susceptible to cell death after an apoptotic stimulus such as H_2O_2. The analysis of mutants involved in yeast apoptosis-like death suggests that the observed cell death is Ycal independent and mainly mediated through Nuclp.