THE SALMONELLA TYPHIMURIUM FLGM GENE, WHICH ENCODES A NEGATIVE REGULATOR OF FLAGELLA SYNTHESIS AND IS INVOLVED IN VIRULENCE, IS PRESENT AND FUNCTIONAL IN OTHER SALMONELLA SPECIES

摘要

FlgM inhibits the flagella-specific sigma factor FliA and is involved in the mouse-virulence of Salmonella typhimurium. In recent experiments, we observed that: (i) a flgM gene that could function to negatively regulate flagella synthesis was present in a variety of salmonellae; and (ii) the flgM gene derived from Salmonella species that are not normally virulent in mice could complement the S. typhimurium flgM mutant for virulence. Our results suggest that a functional flgM has been retained in most, and perhaps all, Salmonella species, regardless of the motility or virulence phenotype of the strain. [References: 19]