Chemical functionalization and modification of surface-bound cystamine-glycine monolayers on gold nanoparticles

摘要

Herein,we report the synthesis,characterization,and post-functionalization of Au nanoparticles that have been surface-modified with glycine-cystamine(Gly-CSA)stabilizing groups.We show that Au monolayer protected clusters(MPCs)can be synthesized via the Brust-Schiffrin method using a Boc-Gly-CSA stabilizer,followed by efficient removal of the Boc protecting group with trifluoroacetic acid.The resulting Gly-CSA Au MPCs are characterized via UV-vis,TEM,and ~1H NMR,and are stable in solution over long periods of time.Finally,we show that the Gly-CSA Au MPCs can be further functionalized with nearly stoichiometric yields using activated esters of stearic acid and a Bodipy dye derivative.Thus,this work provides an alternative,general approach for the modification of the surface chemistry of MPCs.