Fast route to tailor-made proteins

摘要

A renaissance in the use of Large polypeptides and proteins as therapeutic agents has led to significant interest in synthetic technologies to rapidly and efficiently access these biomolecules. Peptide ligation methods have revolutionised protein science and provided an avenue to make polypeptides and proteins with tailor-made modifications to maximise specificity and activity or to probe biological function. One of the key problems remaining in the field is that it still takes an unacceptably long time to synthesise a given protein.