Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a distinct clinical entity of unknown origin, characterized by the acute onset of multiple lesions at the posterior retinal pole at the pigment epithelium level. The clinical course is usually self-limited. In this report, a case of APMPPE emerging simultanously with sarcoidosis and CNS vascular abnormalities is described, suggesting that APMPPE is associated with a generalized inflammatory disease.
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