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Tocilizumab for retinal vasoproliferative tumor secondary to juvenile idiopathic arthritis-associated uveitis: A case report

机译:托珠单抗治疗继发于青少年特发性关节炎相关性葡萄膜炎的视网膜血管增生性肿瘤:一例报告

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摘要

Retinal vasoproliferative tumors (VPRTs) are highly vascularised masses of the neuro-sensory retina. These benign tumours have been classified as idiopathic or secondary. This secondary type has been associated with predisposing lesions such as pars planitis or other inflammatory events [1]. In some cases, visual acuity may be profoundly impaired owing to progressive exudation involving the macular region with macular exudation or cystoid macular edema Interleukin (DL)-6 receptor blockade using tocilizumab (TCZ) proved effective for many autoimmune or inflammatory diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis (JIA), and large-vessel vasculitides [2]. Here, we present a case of intractable case of VPRT secondary to JIA-associated uveitis who favourably responded to TCZ.
机译:视网膜血管增生性肿瘤(VPRTs)是神经感觉视网膜高度血管化的肿块。这些良性肿瘤已被分类为特发性或继发性。这种继发性疾病与易感病灶(如腮腺炎或其他炎症事件)有关[1]。在某些情况下,由于进行性渗出涉及黄斑区域并伴有黄斑渗出或囊状黄斑水肿,使用托珠单抗(TCZ)对白细胞介素(DL)-6受体的阻滞作用已证明对许多自身免疫或炎性疾病(例如类风湿病)有效,因此视力可能会严重受损关节炎,青少年特发性关节炎(JIA)和大血管血管炎[2]。在这里,我们介绍了JIA相关性葡萄膜炎继发于TCZ的难治性VPRT病例。

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