Self-assembled nanostructures from peptide-synthetic hybrid block copolymers:Complex,stimuli-responsive rod-coil architectures

摘要

The synthesis,solution and solid state self-assembly properties of a series of polyisoprene-b-poly(epsilon-benzyloxycarbonyl-L-lysine)PI-b-PZLys and polyisoprene-b-poly(L-lysine)PI-b-PLys block copolymers have been examined.The formation of stimuli-responsive micelles in water has been studied as a function of pH and ionic strength using static and dynamic light scattering,UV-circular dichroism and transmission electron microscopy.The observed change in the micelles dimensions has been directly attributed to the conformational transition in the secondary structure of polypeptide chains.In bulk,these rod-coil copolymers form self-assembled structures that have been characterized using DSC,DMA,WAXS and SAXS techniques.Hexagonal in lamellar(HL)and more interestingly hexagonal in hexagonal(HH)morphologies have been evidenced as a function of the chemical composition.