Plantar basal cell carcinoma in a patient with xeroderma pigmentosum: importance of dermoscopy for early diagnosis of nonpigmented skin cancer.

摘要

Madam, Basal cell carcinoma (BCC) is the most common type of skin cancer in white populations but only a small minority of these lesions is seen on acral locations. The presentation of BCC on acral sites has been related to predisposing factors such as Gorlin-Goltz syndrome (GGS), trauma, scar, radiation or intake of carcinogens such as arsenic. Xeroderma pigmentosum (XP) is a rare autosomal recessive, cancer-prone genodermatosis characterized by a defect in the repair of DNA damage caused by ultraviolet radiation (UVR), which induces a 1000-fold increased risk to develop cutaneous malignancies.