Sporadic fundic gland polyps and proximal polyposis associated with gastric adenocarcinoma share a common antral G cell hyperplasia

摘要

We read with great interest the article by Worthley et al that recently appeared in your Journal, and the subsequent letter on the same subject.2 We would like to make some comments on this interesting topic.Worthley et al reported a new autosomal dominant syndrome that they named gastric adenocarcinoma and proximal polyp-osis of the stomach (GAPPS). GAPPS appears to be characterised by proximal gastric polyposis, particularly of the fundic gland type that often displays low and high grade dysplasia with early development of gastric cancer. These patients showed no evidence of colonic polyps, and other genetic syndromes were excluded. Yanaru-Fujisawa et al reported a further family with GAPPS.