Colonic colonisation with Giardia lamblia in a patient receiving fibrates.

摘要

We read with interest the article by Troeger et a! exploring the epithelial barrier dysfunction related to duodenal Giardia lamblia infection {Gut 2007;56:328-35). Not only does this protozoan interact with the intestinal epithelium but also its life cycle depends on its host's bile metabolism.We report here on a patient for whom treatment with fibrate was likely to facilitate Giardia lamblia colonic colonisation. A 72-year-old woman reported a 1 -year history of diarrhoea. She had a past history of type 2 diabetes, hypertension and hypercholesterolae-mia. She was treated with metformin, glime-piride, enalapril, furosemide and fenofibrate. She had had a 30 kg loss of weight in the past year.(from 90 to 60 kg, 157 cm) but no haematochezia, Vomiting or abdominal pain.