COX-2 expression in adenoma: an imperfect marker for chemoprevention.

摘要

Four randomised, placebo-controlled studies have each shown that daily aspirin use reduces the occurrence of colorectal adenomatous polyps among individuals with a history of prior colorectal adenomas or cancer.1"4 In one of these trials, conducted by the Association pour la Prevention par 1'Aspirine du Cancer Colorectal (APACC), 272 patients were randomised to two doses of a soluble aspirin salt (lysine acetylsalicylate) at 160 mg or 300 mg or placebo after removal of at least three adenomas or one adenoma at least 6 mm in diameter in a clearing colonoscopy.