HIV protein gp120 and chemokines receptor for liver fibrosis.

摘要

Liver disease has become the second most common cause of death of HIV-infected patients,1 and the risk of liver-related death increases with progressive HIV-associated immunodeficiency.2 This observation allows for the possibility that the pathogenic mechanisms which promote T cell depletion may also promote liver injury. In HIV-infected patients, liver disease occurs most commonly from hepatitis C virus (HCV) co-infection, active hepatitis B virus (HBV) infection, non-alcoholic steatohe-patitis (NASH)3 as well as alcohol-associated steatohepatitis.