Effectiveness of conventional, low-dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study: comment.

摘要

Madam, I read with great interest the article by Lee et al. entitled 'Effectiveness of conventional, low-dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study'. Low-dose and intermittent-dose isotretinoin regimens for acne have recendy received considerable attention because of the intriguing potential they offer of comparable efficacy with fewer and less severe side-effects, as well as decreased costs.This is especially true for moderate acne, as studied by Lee et al. I applaud Lee et al. for their ambitious and important attempt to compare conventional and nonconventional isotretinoin doses in a prospective, randomized, open trial with blinded assessment. However, I would like very respectfully to note several aspects of their study which make me question their conclusions. First, the 'conventional' regimen used in their study is, in my opinion, not very conventional. In their trial, Lee et al.