Adverse drug reactions reported for systemic antibacterials in Danish children over a decade.

摘要

Systemic antibacterials are among the most frequently prescribed drugs in children to treat respiratory tract infections [1,2]. Empirical studies have shown that Danish children receive more broad-spectrum penicillins compared with children in Italy, Canada and Scandinavia [3-5].Worldwide, health authorities have published guidelines on appropriate antibacterial prescribing to minimize the development of antibacterial resistance at the population level [6]. In Denmark, the National Board of Health recommends phenoxymethylpenicillin as the drug of first choice to treat respiratory tract infections in children [7]. Use of antibacterials may have negative effects such as bacterial resistance, and may involve adverse drug reactions (ADRs) [8,9].