Fast, solvent-free, highly enantioselective three-component coupling of aldehydes, alkynes, and amines catalysed by the copper(II)pybox complex under high-vibration ball-milling

摘要

Chiral propargylamines were synthesized in good to excellent yields with high enantioselectivity via Cu(OTf)(2)/Ph-Pybox catalysed, solvent-free three-component asymmetric coupling of aldehydes, alkynes and amines by ball-milling within 60 minutes. The catalytic system can be reused several times without losing the activity.