Dietary Effect of Punicic Acid on Oxidative Behavior and Lipid Profiles of Brain,Heart,Liver and Kidney Tissue Lipid of Rats

摘要

This experimental study comprises in vivo oxidative behaviour of punicic acid(9 cis,11 trans,13 cis-18:3 fatty acid),occurring in snake gourd seed oil,when blended with soybean oil at various percentages,soybean oil being the control.The difference in the ratios of n-6/ n-3 PUFA(polyunsaturated fatty acids)is noticeable,particularly the ratio of n-3 PUFA/ PA(punicic acid).The amount of 18:2 and 18:3 in the plasma lipid was found to be maximum with rats raised on 0.6 punicic acid,followed by 1.2 punicic acid,which showed greater polyunsaturation,especially that of EPA(eicosapentaenoic acid)and AA(arachidonic acid).The amount of DHA(docosahexaenoic acid)was found to be maximum with rats fed 2.4 punicic acid,followed by 0.6 and 1.2,respectively.Evaluation of the antioxidant activity in the various tissues revealed distinct variations,in the trend of oxidative behaviour at dose dependent levels.At 2.4 punicic acid in the brain and liver lipid,total cholesterol seemed to decrease while,the same phenomenon was observed at 0.6 level in the heart tissue.